Pathogen Program
Supervisors

Pathogen Program

Transforming how the world understands and responds to infectious disease.

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Senior Director Device Science

Dr James Clarke

James Clarke (also known as JC) is the Senior Director - Product Science in the Pathogen Project at EIT. He is responsible for developing the instrument and disposables needed to extract DNA or RNA from biological samples and prepare that material for sequencing. The aim of the project is to produce a cost-effective, small-scale device that will make the process of sequencing unknown pathogens as robust and simple as possible. Successful completion of the project will enable wider adoption and scalable deployment of EITs pathogen products and services.

A pragmatic and empirical scientific leader, James enjoys transforming early phase scientific concepts into disruptive products. James was one of the first scientists to join Oxford Nanopore Technologies, after finishing a post-doc at Oxford with the company’s scientific founder, Prof. Hagan Bayley. His group was the first team in the world to sequence DNA using a nanopore in early 2011. During James’ 18 years at Oxford Nanopore, he contributed to many projects in R&D and led the Research Division for over a decade, before becoming VP Platform Technology where he oversaw the development of the platform through to manufacturing.

James has a MSci in Chemistry and a PhD in membrane biophysics from Imperial College London. He has led multi-disciplinary teams in a wide range of scientific fields including single-molecule sensing, MEMs fabrication, electrochemistry, surface science, enzyme engineering, biosensors, machine learning, and DNA synthesis.

James enjoys cycling, resistance training, swimming, trips to Cornwall, and building Star Wars Lego with his two children.

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Careers inPathogen Program

The Pathogen Program is developing an end-to-end diagnostic tool to support the diagnosis, prevention and treatment of infectious diseases, starting with respiratory infections and sepsis. A database of global sequencing data will provide the crucial information needed to explain the origin of the pathogen and whether it is resistant to existing treatments. This type of full-stack system will be beneficial in diagnosing disease and supporting pandemic preparedness in the future.

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"I'm very excited about EIT because of this vision of attacking the problems end-to-end, starting from research to building a pipeline all the way to a product, to the way to deliver that product. It's a very unique vision and opportunity to be part of this whole cycle of delivery and impact. At EIT, AI researchers work hand-in-hand with domain scientists, ensuring that AI models are developed to address problems of societal value."

—Dr Danilo Jimenez RezendeExecutive Director & Principal Scientist, AI & Robotics Institute