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Materials & Devices for Life Sciences
Applying multidisciplinary research to redefine nanopore technologies and progress new approaches in tissue engineering that will impact personalised diagnostics and therapeutics.
Professor Hagan Bayley
Professor Hagan Bayley’s laboratory pioneered the engineering of membrane proteins. His work has contributed to our understanding of these proteins, and especially to their use in biotechnology, including the development of a variety of single-molecule applications of protein pores for stochastic sensing and biopolymer sequencing. In 2005, Hagan founded Oxford Nanopore Technologies, which developed the MinION for the nanopore sequencing of DNA and RNA.
Recently, Hagan’s laboratory has explored the application of three-dimensional printing and related technologies for the fabrication of both synthetic tissues and living tissues. Synthetic tissues are materials that resemble living tissues, but the constituent compartments cannot divide. Synthetic tissues can synthesise and deliver drugs or act as soft miniature iontronic components.
Fabricated living tissues contain living cells deposited in predetermined patterns and can be used to screen drugs and will eventually be employed for organ repair. Hybrid synthetic / living tissues are an intriguing prospect.
In 2011, Hagan was elected a Fellow of the Royal Society; in 2019 he was awarded the Royal Society Mullard Award for the invention of stochastic sensing with nanopores; and in 2023 he won the Royal Society Buchanan Medal to recognise his role in the founding of Oxford Nanopore Technology.
Hagan is Professor of Chemical Biology at the University of Oxford.
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Careers inMaterials & Devices for Life Sciences
The MDLS Institute leads research programs in tissue construction and nanopores. Its tissue construction program aims to build the capability to create any tissue - including human tissue - to transform medicine, research and robotics. On-demand tissue production will help improve disease modelling and the building of life-like components for bio-integrated systems. Its nanopores program develops nanoscale systems capable of detecting or sequencing any molecule found in air, water, biological systems or industrial environments. This has the potential to help with early detection and real-time monitoring in areas such as healthcare diagnostics (e.g. breath tests for certain diseases) or environmental safety.


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