

Generative Biology Institute
Building a faculty of leading researchers to tackle the key challenges in making biology engineerable and unlock its potential to benefit humanity.
Kiarash Jamali
Kiarash gained a BSc in mathematics and statistics from the University of Toronto, St George in 2016 and also studied at the Vector Institute as a machine learning researcher being supervised by Frank Rudzicz.
In the summer of 2019, as part of UofT's PEY programme, he worked as a machine learning researcher at RBC Capital Markets on the Aiden project. After graduating in the winter of 2020, he worked for Semantic Health as a machine learning scientist using NLP to help hospitals maximize the use of their data.
In 2025 Kiarash was awarded a PhD at the MRC Laboratory of Molecular Biology under the supervision of Sjors Scheres. This focussed on applying deep learning to cryogenic electron microscopy (cryo-EM) to create automated atomic model building in cryo-EM maps. He also works on heterogeneous reconstruction algorithms using VAEs, machine learning for protein design (ADFLIP).
At GBI Kiarash is developing deep learning algorithms to generate novel proteins with atomic-level accuracy, targeting functions not found in nature.
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Work withKiarash Jamali
The GBI team aims to unlock the blueprint of life, enabling the rapid and scalable synthesis of entire genomes with newfound precision. Success would enable the identification and potential creation of DNA sequences that could generate biological systems designed to perform specific functions. These new DNA construction techniques could have a wide range of commercial applications, including designing more efficient crops with higher yields or finding personalised cell therapies and vaccines. Specially engineered cell processes could also support new biodegradable materials to help tackle the problems of climate change.
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—Dr Danilo Jimenez RezendeExecutive Director & Principal Scientist, AI & Robotics Institute

