Jerry S.H. Lee, PhD

Chief Science and Innovation Officer, Ellison Institute of Technology
Associate Professor of Clinical Medicine, Chemical Engineering & Material Sciences, and Quantitative & Computational Biology, USC

310 228 6400

Dr. Lee is the Chief Science and Innovation Officer at the Ellison Institute of Technology and an Associate Professor of Clinical Medicine, Chemical Engineering and Material Sciences, and Quantitative and Computational Biology at the University of Southern California Keck School of Medicine, Viterbi School of Engineering, and Dornsife College of Letters, Arts, and Sciences. He provides leadership, guidance, vision, and development of research capabilities for executing the Institute’s research projects and will be responsible for planning, implementing, and evaluating scientific direction, projects, and funding to sustain high-impact programs in support of a bold vision to transform cancer research in the 21st century.

Prior to joining the Institute, Dr. Lee served for more than a decade as a Health Sciences Director within the National Cancer Institute’s Office of the Director. Through direct support and use of public-public/public-private partnerships, he deployed programs focused on the integration of advanced technologies, trans-disciplinary approaches, infrastructures, and standards, to accelerate the creation of publicly available, broadly accessible, multi-dimensional data, knowledge, and tools to empower the entire cancer research continuum for patient benefit.

In 2016, Dr. Lee was assigned to Office of the Vice President to serve as the Deputy Director for Cancer Research and Technology for the White House Cancer Moonshot Task Force. A few key efforts he helped coordinate include the Applied Proteogenomics Organizational Learning and Outcomes (APOLLO) Network, international collaborations to share molecular characterization datasets, the Blood Profiling Atlas in Cancer pilot, as well as co-chairing an interagency group focused on cancer data and technology policy issues.

Dr. Lee’s research involves elucidating the interplay between biophysical and biochemical drivers of age-related diseases and has co-authored over thirty papers, five book chapters, and one book. He is a member of the Department of Veterans Affairs’ National Research Advisory Council, the National Academies Board on Science, Technology, and Economic Policy’s Innovation Policy Forum, and the Health and Environmental Sciences Institute’s Board of Trustees. Dr. Lee earned his B.S. degree in biomedical engineering and Ph.D. in chemical and biomolecular engineering from Johns Hopkins University.

Research Focus

Cell and tissue biophysics
Cell migration and motility
Data-driven molecular medicine
Adaptive learning healthcare system



2001 Biomedical Engineering – Johns Hopkins University, Baltimore, MD 


2006 Chemical and Biomolecular Engineering- Johns Hopkins University, Baltimore, MD   


National Cancer Institute Director’s Merit Award, 2010 – 2012, 2014 – 2017

NASA Graduate Student Research Fellowship Award, 2004 – 2006

Tau Beta Pi, 2004

Leadership Positions

  • Trustee, Health and Environmental Sciences Institute
  • Appointed Member, National Research Advisory Council to the Secretary, Department of Veterans Affairs
  • Innovation Initiative Member, Health Services Research and Development Scientific Merit Review Board, Department of Veterans Affairs
  • Founding Member, Innovation Policy Forum of the Board on Science, Technology, and Economic Policy, National Academies of Sciences, Engineering, and Medicine (NASEM) Co-founder and Co-chair, Blood Profiling Atlas in Cancer (BloodPAC)
  • Co-founder and Consultant, Applied Proteogenomics OrganizationaL Learning and Outcomes (APOLLO) Research Network, Henry M. Jackson Foundation
  • Founding Co-chair, High Content Data Integration Working Group, Biomarkers’ Consortium Cancer Steering Committee, Foundation for the National Institutes of Health National Research Advisory Council, Advisory Committee Management Office
  • Advisory Board Member, Accelerating Therapeutics for Opportunities in Medicine (ATOM) Consortium
  • Member, John P. Murtha Cancer Center at the Walter Reed National Military Medical Center

Selected Publications

Lee, J.S.H., K.M. Darcy, H. Hu, Y. Casablanca, T.P. Conrads, C.L. Dalgard, J.B. Freymann, S.E. Hanlon, G.D. Huang, L. Kvecher, G.L. Maxwell, F. Meng, J. Moncur, C. Turner, J.M. Wells, M.D. Wilkerson, K. Zhu, R.B. Ramoni, C.D. Shriver. From Discovery to Practice and Survivorship: Building a National Real-World Data Learning Healthcare Framework for Military and Veteran Cancer Patients. Clinical Pharmacology and Therapeutics, 2019. View: here

Lee J.S.H., Kibbe W.A., Grossman R.L. Data Harmonization for a Molecularly Driven Health System. Cell, 2018. View in: PubMed.

Lee JS, Hale CM, Panorchan P, Khatau SB, George JP, Tseng Y, Stewart CL, Hodzic D, Wirtz D. Nuclear lamin A/C deficiency induces defects in cell mechanics, polarization, and migration. Biophys J. 2007 Oct 1;93(7):2542-52. View in: PubMed

Wu P.H., Aroush D.R., Asnacios A., Chen W.C., Dokukin M.E., Doss B.L., Durand-Smet P., Ekpenyong A., Guck J., Guz N.V., Janmey P.A., Lee J.S.H., Moore N.M., Ott A., Poh Y.C., Ros R., Sander M., Sokolov I., Staunton J.R., Wang N., Whyte G., Wirtz D. A Comparison of Methods to Assess Cell Mechanical Properties. Nature Methods. 2018. View in: PubMed

Keating, S.M., D.L. Taylor, A.L. Plant, E. Litwack, P. Kuhn, E.J. Greenspan, C.M. Hartshorn, C.C. Sigman, G.J. Kelloff, D. Chang, G. Friberg, *J.S.H. Lee, *K. Kuida. Opportunities and Challenges in Implementation of Multiparameter Single Cell Analysis Platforms for Clinical Translation. Clinical and Translational Science. 2018. View in: PubMed

Phillip, J.M., P. Wu, D.M. Gilkes, W. Williams, S. McGovern, J. Daya, J. Chen, R. Fan, J.S.H. Lee, J. Walston, D. Wirtz. Biophysical and Biomolecular Determination of Cellular Age in Humans. Nature Biomedical Engineering. 2017. View: here

Carr, S.A., S.E. Abbatiello, B.L. Ackermann, C. Borchers, B. Domon, E.W. Deutsch, R.P. Grant, A.N. Hoofnagle, R. Huttenhain, J.M. Koomena, D.C. Liebler, T. Liu, B. MacLean, D.R. Mani, E. Mansfield, H. Neubert, A.G. Paulovich, L. Reiter, O. Vitek, R. Aebersold, L. Anderson, R. Bethem, J. Blonder, E. Boja, J. Botelho, M. Boyne, R.A. Bradshaw, A.L. Burlingame, D. Chan, H. Keshishian, E. Kuhn, C. Kinsinger, J.S.H. Lee, S. Lee, R. Moritz, J. Oses-Prieto, N. Rifaio, J. Ritchiep, H. Rodriguez, P.R. Srinivas, R.R. Townsend, J. Van Eyk, G. Whiteley, A. Wiita, S. Weintraubt. Targeted Peptide Measurements in Biology and Medicine: Best Practices for Mass Spectrometry-based Assay Development Using a Fit-for-Purpose Approach. Molecular and Cellular Proteomics. 2014. View in: PubMed

Sun C, Lee JS, Zhang M. Magnetic nanoparticles in MR imaging and drug delivery. Adv Drug Deliv Rev. 2008 Aug 17;60(11):1252-65. 0. View in: PubMed

Lee JS, Panorchan P, Hale CM, Khatau SB, Kole TP, Tseng Y, Wirtz D. Ballistic intracellular nanorheology reveals ROCK-hard cytoplasmic stiffening response to fluid flow. J Cell Sci. 2006 May 1;119(Pt 9):1760-8. View in: PubMed

Lee JS, Chang MI, Tseng Y, Wirtz D. Cdc42 mediates nucleus movement and MTOC polarization in Swiss 3T3 fibroblasts under mechanical shear stress. Mol Biol Cell. 2005 Feb;16(2):871-80. View in: PubMed